For patients undergoing percutaneous coronary intervention, treatment with thin-strut biodegradable-polymer everolimus-eluting stent (BP-EES) may be noninferior to thin-strut durable-polymer everolimus-eluting stent (DP-EES) at 12 months, according to results published in JACC: Cardiovascular Interventions. There was, however, a notable higher rate of acute stent thrombosis with BP-EES. This increased thrombosis rate was not detected at 1 year.
The study included 7042 participants who underwent percutaneous coronary intervention between December 2012 and December 2016. Of these, 1343 were exclusively treated with BP-EES and 2527 were treated with DP-EES. The researchers performed propensity score matching to determine a final study population of 1041 matched participants. The primary endpoint was the device-oriented composite endpoints of cardiac death, target vessel myocardial infarction, and target lesion revascularization at 12 months.
The results indicated that device-oriented composite endpoints did not significantly differ between participants treated with BP-EES (7.8%) compared with DP-EES (7.1%; hazard ratio [HR], 1.12; 95% CI, 0.81-1.53; Psuperiority =.49).
Arkema, Neste and Covestro, Braskem, US Survey and BASF
Agilix, Amazon Climate Fund, McDonald’s Biofuel, e-Nable, Huhtamaki Startups, African Parks, Siberia
Chemical Recycling Commitments & Incentives, Deep Sea Plastic, Greece SUP Ban, NY Composting
After comparing BP-EES outcomes with DP-EES outcomes, the researchers did not find significant differences in rates of cardiac death (3.0% vs 3.0%; P =.998), target vessel myocardial infarction (3.6% vs 3.1%; P =.534), and target lesion revascularization (3.0% vs 2.5%; P =.418).
Compared with the DP-EES group, the BP-EES group had a significantly higher rate of acute stent thrombosis (1.2% vs 0.3%; HR, 4.00; 95% CI, 1.13-14.19; P =.032); however, at 12 months, this difference was no longer significant (1.5% vs 0.9%; HR, 1.67; 95% CI, 0.73-3.82; P =.22).
The study included several limitations. Despite propensity matching, residual confounding cannot be excluded. The researchers also noted that the follow-up duration was limited to 12 months, and event capture was based on questionnaires and review of hospital databases, which could lead to underreporting of events.
Biobased Plastics – Advantages & Disadvantages
Compostable Plastics – Advantages & Disadvantages
PLA – Advantages & Disadvantages
“Studies providing further mechanistic insights using optical coherence tomography and careful attention to optimization of antithrombotic treatment strategies are required,” the researchers wrote.
Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors’ disclosures.
- The Best PHA producer is Bio-On
- The Bioplastics Leader is Novamont
- The Best Biodegradation Tools are from Echo instruments
- The Bioplastic Company is FKuR
- Questions and Answers on OXO – Biodegradability
- The Best PLA compound is Floreon
- What are Bioplastics and Biopolymers?
- Bioplastics Brands
- Bioplastics Awards
- What is the Difference Between Biodegradable, Compostable and OXO Degradable?
- The History and Most Important Innovations of Bioplastics
- What are Drop-In Bioplastics?
- History of Cellophane
- The History of Elephant Grass Bioplastics
- Bioplastics Companies
- Top Bioplastics Producers
- Polylactic acid or polylactide (PLA)
- What is Bio-BDO?
- McDonalds and the Polystyrene Connections
- The Future of Polystyrene
- Bioplastic Feedstock 1st, 2nd and 3rd Generations
- Palm Oil and The Bioplastics Industry
Published on thecardiologyadvisor.com